19 Jun 10 Botox Side Effects
Mom recently admitted to having ANOTHER Botox side effects that has been with her from the beginning, she said, and that is her eyes move rapidly from left to right over and over again. This is also known as eye fasciculation. Yet another neurological tick caused by the Botox.
Will it ever end!?!?
06 Jun 10 Botox and Insomnia
Mom hasn’t slept a wink in over a year! I mean, she sleeps and all, but it seems one of the major side effects to Botox injections is insomnia. She sleeps in what she calls “sections of time,” where she doesn’t sleep through the night but only in certain intervals.
This gets weirder by the day. I’ll tell ya!
Thankfully, Mom found Ambien, and that helps her avoid a confused state when she wakes up.
06 Jun 10 Botox Causes Confusion Mental State
Mom had another confusion spell that lasted until 6am. Nothing seemed to help. Her helper left for his girlfriends house, but he left a note, which helped reassure her.
What triggered it?
Mom had an argument with Dad. Too much mental stimulation/stress seems to trigger these things. Mom said the Botox event is a “linear occurance.” At its worst, she regresses back to the worst neuro symptoms.
Sadly, she didn’t even know who lived with her until she found the note from helper or not. She didn’t know if she was hungry or not. She didn’t know if she should go to bed or not.
Emotionally, she said its a feeling of fear and anxiety.
God damn, this better not be permanent… it takes my breath away when I think about it.
03 Jun 10 Botox Alternative
Johnson & Johnson Buys Mentor
Drug giant Johnson & Johnson recently bought out cosmetic drug company, Mentor, for $US1.07B bucks. How is this relevant to Botox?
Mentor is currently awaiting FDA approval for its Botox alternative drug. Mentor is also the only rival to Allergan’s silicone breast implant product. Expect the two to go head to head, or shot to shot (pun intended), in both markets, all of which comprise what is known as the “asthetics” space.
Asthetics involve all drugs and related stuff that aids in fighting age-related cosmetic changes. By 2012, the asthetic market may grow into a $US7B industry due to baby boomers rocketing off into old age and their vanity-consciousness guiding their wallets.
From Bloomberg:
Dec. 1 (Bloomberg) — Johnson & Johnson announced its second acquisition in a week, drawing on stockpiled cash to buy the breast-implant maker Mentor Corp. for $1.07 billion.
Holders of Mentor will get $31 a share, almost double last week’s close, in a deal that pushed the stock within cents of the offer price. Allergan Inc., a maker of implants and the wrinkle treatment Botox, dropped 11 percent on the prospect of competing with J&J, the world’s largest health-care company.
J&J said last week it would buy Omrix Biopharmaceuticals Inc., a maker of surgical equipment to stanch bleeding, for $438 million. The deals suggest J&J, with more than $14 billion in cash on its balance sheet at the end of September, may be on a shopping spree for undervalued companies, said John Farrall, a health-care analyst with National City Private Client Group in Cleveland, which manages $125 million in J&J stock.
“This is right down J&J’s alley of a smaller player with decent products that they can just move right through their distribution network,” Farrall said today in a telephone interview.
Mentor, based in Santa Barbara, California, is the world’s leading seller of breast implants and also sells equipment used in liposuction and facelifts, all offerings new to New Brunswick, New Jersey-based Johnson & Johnson. The acquisition would be a “keystone” of the J&J’s efforts to enter the $4.6 billion market for cosmetic medical products, said Gary Pruden, president of Ethicon, the unit that will oversee Mentor.
Good Aesthetics
Worldwide sales for the “aesthetic” market are expected to grow to as much as $7 billion by 2012, he said. With the global population growing older, and obesity on the rise, J&J sees promise even if breast surgeries have slowed recently in the weak economy, Pruden said by phone.
“The short-term economic view is not one that we think undermines our long-term strategy,” he said.
J&J offers Mentor the sales, marketing and doctor-training force that will help expand business outside the U.S., Josh Levine, Mentor’s chief executive officer, said today in a telephone interview.
Mentor shares rose 89 percent to $30.58 at 4:02 p.m. J&J dropped $3.25, or 5.6 percent, to $55.33. Allergan slid $4.27, or 11 percent, to $33.41. All three trade on the New York Stock Exchange.
Allergan, of Irvine, California, and Mentor are the only companies offering silicone breast implants in the U.S. The Food and Drug Administration approved their use for cosmetic surgery in 2006, after 14 years of allowing them only for breast reconstruction due to safety concerns.
Botox Rival
Mentor also is seeking FDA approval for a wrinkle-filling injection expected to compete against Botox, Allergan’s market- leading cosmetic product.
Breast-implant sales fell in the last quarter and are likely to continue to slide next year because of the U.S. recession, Farrall said.
Still, at about three times expected earnings, the price is “not that much” for Johnson & Johnson relative to other recent acquisitions in the drug and medical device industry, he said. Mentor traded as high as $40.82 on Jan. 4.
“The move into breast implants may surprise some, given the history of litigation and liability risk in the space,” said Michael Weinstein, a JPMorgan Chase & Co. analyst in New York, in a note to clients today.
“J&J, however, appears comfortable enough with the risk profile after months, if not years, of due diligence on the opportunity,” said Weinstein, whose note saw “little to no chance” of a competing bid emerging.
Revenue Decline
Mentor generated $373.2 million in sales in the fiscal year ended in March, 88 percent from breast implants. Implant revenue dropped to $74.4 million in this year’s fiscal second quarter, which ended Sept. 27, from $93.9 million in the previous three months.
The acquisition is expected to close in the first quarter of 2009 and will hurt J&J’s earnings by 3 cents to 5 cents a share for the year, according to the statement. When net debt is included, the deal is valued at $1.12 billion.
Mentor is getting advice on the transaction from Citigroup Inc. and Morrison & Foerster LLP. Johnson & Johnson is using Cravath, Swaine & Moore LLP.
Unfortunately, J&J didn’t do their dilligence with the long term Botox side effects…
02 Jun 10 Botox Affects Brain Stem
From Natural Health:
The botulinum toxin injected into the face from the popular drug Botox can move into the brain, where it may cause damage to the central nervous system, according to a study published in the Journal of Neuroscience.
Allergan Inc.’s best-selling drug Botox, used to smooth out wrinkles by relaxing facial muscles, is actually botulinum neurotoxin type A. The toxin functions by disrupting the signals of the nervous system. Botox and a different variety of botulinum toxin, marketed as Myobloc by Solstice Neurosciences, are also used to treat muscular stiffness or spasms caused by conditions such as cerebral palsy.
After reports surfaced of people experiencing trouble breathing or swallowing after receiving injections of the toxin, the FDA added warnings to the labels of Botox and Myobloc about these effects. While the FDA has only warned of the effects in patients with neuromuscular disorders, it has acknowledged that a risk might also be posed in other people and has launched an investigation.
The reason for the danger is that the botulinum toxin might migrate from its injection site into other parts of the nervous system.
In the current study, researchers injected botulinum toxin into one side of the hippocampus into the brains of rats, and observed it to migrate to the other side of the brain. When the toxin was injected into the brain’s superior colliculus, which is involved in vision, it migrated into the animals’ eyes.
Six months after the initial injection into the hippocampus, the researchers could still observe the toxin’s effects.
Botulinum toxin is produced by the bacteria Clostridium botulinum, which is known to infect wounds and contaminate food. Approximately 110 cases of botulism poisoning occur in the United States each year. Because of the toxin’s tendency to paralyze the respiratory system, botulism contamination can be fatal if not treated.
30 May 10 Botox Lawsuit – Allergan Loses
Anyone sue Allergan yet over Botox? They’re starting to roll in. I wonder when Mom is going to sue Allergan? I know the reason she hasn’t yet is due to the mental and physical stress she’d have to endure reliving the worse moments of her life. But, maybe one day. Until then, the silent ones, like Mom, will speak loudly:
OKLAHOMA CITY — A jury in Oklahoma County has found the maker of Botox negligent and awarded $15 million to a doctor who said she suffered botulism after using the anti-wrinkle drug.The jury found Allergan Inc. negligent on Tuesday because the label on the product did not include enough information about potential side effects. It awarded Dr. Sharla Helton $15 million in actual damages.Helton said she suffered pain and weakness after receiving Botox injections that led her to sell her medical practice and step down as medical director of an Oklahoma City hospital. Allergan spokeswoman Carolyn Van Hove called the ruling “inconsistent with all credible and scientific medical evidence.” She said the company will appeal.
The numbers are growing. May God bless Dr. Helton!
29 May 10 Son of a Bitch
I really hate having to talk about Mom and her Botox problem. It’s like, f–k, this is so damn depressing. It makes me want to turn my head way from Mom, I’m afraid to admit, but of course, I’d never do that.
I guess I’m just ranting.
